Association of GLUT4 gene polymorphisms with risk of coronary heart disease in Han population in Guangdong province

Objective to study the association between the single nucleotide polymorphism(SNP) of glucose transporter-4(GLUT4) gene and the susceptibility of the coronary heart disease(CHD) in Han population in Guangdong province.Methods Genotyping for the two selected tag SNP(rs16956647 and rs5435) in GLUT4 gene was conducted in 1 044 CHD cases and 1 349 health controls by using SNPscanTM Kit.Then, genetic analysis software Plink and statistical analysis software SPSS 17.0 were used to assess the association of the SNP loci with CHD.Results SNP of rs5435 was excluded because it did not agree with Hardy-Weinberg proportions.Significant genotypic association of rs16956647 with CHD was found after adjustment for gender, age, hypertension, diabetes, smoking, total cholesterol, and body mass index(additive model:P=0.016, odd ratioOR=0.8095% confidence interval:0.67-0.96;dominant model:P=0.002, OR=0.710.57-0.89).And further stratification analysis demonstrated that only in the diabetes subgroup, rs16956647 was significantly associated with CHD(additive model:P=0.048, OR=0.820.67-0.99;dominant model:P=0.007, OR=0.720.56-0.91).Conclusion In Han population in Guangdong province, the association of GLUT4 rs16956647 polymorphisms with CHD may be related to the insulin resistance that the gene confers, however, further studies are required to elucidate its molecular mechanism(s) precisely.