Association between XPG gene polymorphisms and susceptibility to gastric cardiac adenocarcinoma

Objective To evaluate the association of xeroderma pigmentosum group G (XPG) gene rs751402 C/T and rs873601 G/A single nucleotide polymorphism (SNP) with the risk of gastric cardiac adenocarcinoma (GCA) in a population of Ci county with high incidence of GCA in Hebei province.Methods XPG gene rs751402 and rs873601 were genotyped with polymerase chain reaction ligase detection reaction (PCR-LDR) method in 431 GCA patients and 432 gender- and age-matched healthy controls.Results The younger individuals (≤61 years old) with XPG rs751402 T/T genotype showed an increased risk of GCA (adjusted odds ratio OR=1.77,95% confidence interval 95% CI=1.12-3.30).No association of XPG rs873601 SNP with the susceptibility to GCA was observed either in overall analysis or in stratification analysis among the participants.Conclusion The XPG rs751402 T/T genotype carriers may have a higher risk of GCA.