Correlation between blood lipids and hyperhomocysteinemia in patients with cerebral infarction

Objective To investigate the correlations between blood lipids and hyperhomocysteinemia in patients with cerebral infarction.Methods A total of 884 cerebral infarction patients were selected from the Second Affiliated Hospital of Harbin Medical University and divided into two groups according to their levels of homocysteine.The association of blood lipids with hyperhomocysteinemia was analyzed.Results High density lipoproteinl cholesterol (HDL) was associated with hyperhomocysteinemia (χ²=17.193,P<0.0001),with an odds ratio (OR) (95% confidence interval95% CI) of 0.420 (0.277-0.638);HDL was also associated with hyperhomocysteinemia with the OR (95% CI)) of 0.352(0.223-0.554) after adjusting for age,sex,education level,smoking,alcohol drinking,and diabetes.Conclusion HDL is a protective factor of hyperhomocysteinemia in patients with cerebral infarction,and the decrease of HDL can increase the incidence of hyperhomocysteinemia.