Association between gene polymorphism of vascular endothelial growth factor receptor 2 and susceptibility of major depressive disorders

Objective To investigate the relationship between vascular endothelial growth factor receptor 2(VEGFR2)gene polymorphism and the susceptibility of major depression disorders.Methods We collected peripheral blood samples from 274 Han patients diagnosed with unipolar depression and 273 age- and gender-matched Han healthy controls in Northeast of China.Single base primer extension assay (Snapshot)was used to detect genotype frequency and allele frequency of VEGFR2+1416 T/A.χ² test was used to analyze the difference in the distribution of genotype and allele between the cases and the controls.Results There was a significant difference between the cases and the controls in the frequency distribution of VEGFR2+1416 T/A genotype A/A(26.3% vs.16.8%),A/T(44.9% vs.54.6%),and T/T (28.8% vs.28.6%)(χ²=8.219,P=0.016).The frequency of VEGFR2+1416 T/A allele of A and T were 48.7% and 51.3% in the cases and 44.1% and 55.9% in the controls,without significant difference between the two groups (χ²=2.310,P=0.129).Conclusion The gene polymorphism of VEGFR2+1416 T/A is correlated significantly with the incidence of unipolar depression.