Objective To explore the effect of antenatal and postnatal lead exposure on infants physical development in lead polluting area.
Methods Prospective cohort study was performed. The newly-wedding couples cohort was found in lead polluting area. Baseline investigation, pre-pregnacy observation, pregnant period follow-up and labour and newborn baby record among them. When their offspring was infant period, physical examination were carried out. Meanwhile, blood were drawn and blood lead levels were measured with atomic absorption spectrophotometry.
Results The difference of Z-standard score for infant height was significant between the high and low lead of mother baseline blood, Z-standard score for infant chest circumferenc in mother and father baselin blood. The difference of height growth rate within 24 months was significant between the high and low lead of mother and father baseline blood, umbilical cord blood. There were negative relation between blood lead levels and Z-standard score and height growth rate.
Conclusion Infants physical development retard caused by lead exposure is associated with antenatal and postnatal exposure even baseline lead load in parent. Prevention of child lead poisoning should begin from antenatal.
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