Effect and mechanisn of Reduping on heat stroke in mice

  Objective   To investigate the effect and mechanism of Reduping, a novel endotox in-antagonist made from traditional Chines medical herds, in the treatment of heat stroke and to provide experimental evidence for the prevention and cure of the disease.

  Methods   The heat stroke model was established under circum stances of dry buld temperature(34.5±0.15)℃ and(60±5)% relative humidity. 40 mice were randomly divided into five groups including reduping group, xihuangqijiao group, Dexamethasone group, heat strike group and normal group and the increased rate of temperature, subsistence time and the number of diarrhea of experimental animals were observed.

  Results   It was observed clearly that the increased rate of temperature, survival time the number of diarrhea of Reduping group were the slowest, longest and most among the these groups respectively.

  Conclusion   Reduping have the better effect of prevention and cure to the heat stroke and one of the most important mechanisms is to improve intestinal function and to excrete more poisonous substances of body.