Effect of octachlorodipropylether on DNA damage of liver and lung cells in mice

  Objective   To study the genetic toxic effect of octachlorodipropylether on mice liver and lung cells.

  Methods   In an in vivo study, mice were sacrificed at 0, 3, 9, 24, 48 and 72 h after oral0, 100, 200, 400 and 800 mg/(kgºbw)administration of octachlorodipropylether. DNA damage was measured by the single cell gel electrophoresis(SCGE)assay.

  Results   After oral administration400 and 800 mg/(kgºbw), DNA damage appeard in the liver at 9, 24 h, and in the lung at 9, 24 and 48 h.

  Conclusion   A certain dose octachlorodipropylether has genetic toxic effect on mice.