Relation between environmental pollution caused by free SiO₂ dust and lipid peroxidation in erythrocyte membrane in human

  Objective   To explore the relation between air environmental pollution by free SiO₂ dust and lipid peroxidation degree in erythrocyte embrane in human.

  Methods   179 healthy workers exposed to free SiO₂ dust and 57 healthy members(control group)were sampled by cluster sampling method in two ceramics factories in Foshan city of Guangdong province, and a cross sectional investigation was carried out in up-related population and 2 ml blood in vein was draw from each one. Malondialdehyde(MDA), superoxide ismufase(SOD)and glutathion peroxidase(GSH-px)were tested by method introduced in reagent kits.

  Results   Activity of GSH-px in erythrocyte membrane in workers exposed to free SiO₂ dust was significantly lower than that of control group(P < 0.05), the quantity of MDA in erythrocyte membrane in workers was significantly higher than that of control group(P < 0.05), and activity of SOD in workers was significantly lower than that of control group(P < 0105).

  Conclusion   Air environmental pollution by free SiO₂ dust can cause significant toxicological reaction of lipid peroxidation in erythrocyte membrane in human, the change of degree of lipid perox idation maybe a certain kind of pre-clinical message, and sustain a stable balance state of anti-oxidation system maybe an important strategy for the secondary prevention of toxicological reaction caused by free SiO₂ dust in human.