Effect of combined iodine and fluoride on phospholipid and fatty acid composition of RBC in rat blood

  Objective   To study the influence of high fluoride(F)and Indine(I)on phospholipid and its fatty acid composition of red blood cell(RBC)in rat blood.

  Methods   Five groups of rats were provided with deionized drinking water containing 0 and 150 mg/L NaF, and containing both 150 mg/L and 0.003, 03 or 3 mg/L KI respectively for 5 months.The plospholipid and its fatty acid composition were analysed using liquid chromatography.

  Results   Compared with control: the content of phospholipid decreased in the combinded of high I and high F group; the proportion of unsaturated fatty acids was decreased and the saturated fatty acids increased in the high F group; the middle conceneration I had cooperation effects on fluorosis.

  Conclusion   High amount of fluoride can induce modification of fatty acid compositions of phospholipid in blood, which might be the result from oxidative stress and the increased level of lipid peroxidation.