Objective To estimate the population attributable risk for environmental and genetic risk factors in the development of gastric cancer.
Methods 1:1 case-control study was carried out in Nanjing area, calculating ARC% for each risk factor of environmental and genetic risk factors in gastric cancer and sAR for all of the risk factors among 121 cases of gastric cancer patients and controls.
Results sAR of tobacco smoking, irregular, pickledfood, family history of digestive system disease accounted for 54.7%.If combined with the genetic risk factors CYP 2E 1 and NAT 2 M 1, sAR increased to 69.7%.The result suggested that genetic polymorphisms and environmental risk factors played co-operated roles in gastric cancer.
Conclusion Preventive strategy should be based on the gentic polymorphisms of different people and environmental risk factors to prevent people from development of gastric cancer.
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