Effect of spirulina on antioxidation of experimental silicosis of rat

  Objective   To explore the effect of spirulina on antioxidation of silicosis.

  Methods   The silicosis model was prepared by non-exposure brnchus injection, rats were divided randomly into three groups: control group, silica group and spiruina+silica group.

  Results   Spirulina could significantly elevate the activitty of SOD and GSH-Px of the silica exposed rats, meantime could reduce the content of MDA in lungs and ACP, LDH in BALF.

  Conclusion   Spriulina possessed the ability of enhancing the antioxidation level of silicosis rat in vivo, partly restraining the development of silicosis; the mechainsm of the effect probably related to nutritional compositions and such as trace element Se and Betacarotene.