Study on antimutagenicity of natural β-carotene to chemical carcinogen

  Objective   To observe the antimutagenic activity of natural β-carotene to chemical carcinogen.

  Methods   The modified V₇₉/HGPRT gene mutation test, modified mice bone marow cells micronucleus test and mice testicle cells chromosome aberration test were applied.

  Results   In V₇₉/HGPRT gene mutation test natural β-carotene could inhibit the mutagenesis of AFB₁(+S₉)and mitomycin C(-S₉)on V₇₉ cells.The micronuclei frequency induced by cyclophosphamidum in mice bone cells and chromosome aberration frequency induced by mitomycin C in mice testicle cells were both inhibited significantly by natural β-carotene.

  Conclusion   Natureal β-carotene had significantly antimutagenicity to chemcial carcinogen and could be applied on chemopreventing tumor and alleviating adverse effects of chemcial treating drugs.