Effects of lycopene on blood lipid and antioxidation in hyperlipidemia rats

  Objective   To study the effects of Lycopene(LP)on blood lipid and antioxidative enzyme in hyperlipidemic rats.

  Methods   Forty male Wistar rats were randomly divided into 4 groups according to body weight and serum cholesterol levels.They were fed one of four diets, a reference diet, a high fat supplemented diet and a high fat supplemented with 10 mg/kg, 20 mg/kg LP.After 5 weeks, blood lipid and antioxidative enzymes capacity were determined respectively.

  Results   Compared with model, LP could reduced the serum TC, TG, LDL-C concentration, increased SOD and GSH-Px activities, decreased MDA content significandy(P < 0.05).

  Conclusion   LP might play an important role in preventing hyperlipidemia through its antioxidative effect.