Effect of extract from phellinus igniarius on tumor growth and cell immunity function

  Objective   To explore effect of extract from phellinus igniarius on tumor growth and function of cell mediated immunity in mouse models.

  Methods   C₅₇ mice were divided into 5 groups by body weight randomly; they were the blank control, negative control and 3 treat groups.Subcutaneous transplantation H₂₂ tumor mouse models were established.Besides of normal feeding, the control mice were fed with physiological saline and the treated mice were fed with different dose of phellinus igniarius to evaluate the tumor response; By experiment of phagocyte in abdominal cavity to phagocytize chicken red blood cell in vitro, method of lactic dehyrogenase and MTT, activity of mono phagocyte NK cell and LAK cell was checked respectively.The treatment effects on index of viscera of brain, thymus gland, liver and spleen were observed.

  Results   Differences between treated groups and control groups in the rate of inhibition and function of cell mediated immunity were statistical significance, but visceral indexes was not statistical significance.The effects of treatment on 4 major visceras was not statistical significance.The optimal feeding dose was 200 mg/(kg°bw).

  Conclusion   Extract from phellinus igniarius could inhibit tumor growth; enhanced function of cell mediated immunity of tumor-bearing mice and the optimal feeding dose was 4 times of the recommendatory dose for human being.