Study on heterogeneity in pedigrees of type 2 diabetes mellitus

  Objective   To explore the heterogeneity of type 2 diabetes mellitus(T2DM)in 115 pedigrees.

  Methods   The KruskalWallis, two peaks and correlation were used by PPAP program.Insulin sensitivity index, pancreas secretion index, B cell function index, insulin resistance index, age of onset, body mass index, waist hip ratio and waistline were analyzed.

  Results   The pancreas secretion index and waistline had significance(P=0.029;P=0.031).The proportions of insulin resistance had significance in male and female(37.9% vs 25.2%, P=0.029).The proportions of insulin sensitivity also had significance(88.9% vs 80.0%, P=0.044).

  Conclusion   Heterogeneity existed in function of pancreas secretion and insulin resistance in the pedigress population of T2DM.