Mechanism of dietary calcium on reducing body weight of obese rats induced by diets

  Objective   To observe the effect of dietary calcium on obese rat and study the mechanism.

  Methods   Obses rat model was induced by high-fat diet.Then obese rats were randomly divided into four groups and were respectively fed with different diets(basic diets, high-fat diet with 0.25% calcium, high-fat diet with 0.5% calcium, high-fat diet with 1% calcium)for 10 weeks.At the end of experiment, the rats were sacrificed.The blood glucose, serum lipids and hormones were measured.

  Results   High dietary calcium reduced the weight and fat pad of obese rats, decreased serum cholesterol, trigly ceride, serum insulin and plasma neuropeptide Y, and increased serum leptin, serum FT3 and growth hormone.

  Conclusion   High dietary calcium affected the levels of serum leptin, plasma neuropeptide Y, serum FT3 and growth hormone, consequently reduced the weight of obses rats induced by high-fat diet.