Interferential effect of calcium antagonists on cadmium nephrotoxicity

  Objective   To explore the interferential effect of calcium antagonists on cadmium nephrotoxicity, and to provide the theory foundation in preventing cadmium toxicity.

  Methods   Using primary renal tubular epithelial cell culture, the interferential effect of calcium antagonists in renal cell harm were investigated by detecting the activity of LDH、ALP、Ca²⁺Mg²⁺-ATPase and the concentration of Ca²⁺、Cd²⁺, meanwhile renal cell pathology changes were detected.

  Results   The activity of LDH、Ca²⁺-Mg²⁺-ATPase in both interferential groups obviously decreased as compared with the cadmium group, while the total cadmium, the non-protein-binding cadmium in nimodipine group did not change as compared with the contrast group, both interferential group could avoid cell harm induced by cadmium in the cell smear.

  Conclusion   Calcium antagonists might have some protection on cadmium-induced renal cell harm.