Relationship between hypertension and clinically probable Parkinson's disease

  Objective   To investigate the relationship between hypertension and clinically probable Parkinson's disease (PPD)in the nutrition-deficient population in Linxian county and provide a basis early prevention and treatment for PD.

  Methods   A prospective cohort study was conducted.The blood pressure data of population were collected from the data of baseline survey to subjects in Linxian Nutrition Intervention in 1985.The diagnosis of PPD was made by two steps.First, the cohort was screened by combining questionnaire and physical examination together.Second, those suspicious cases were polydiagnosed by neutral medical experts coming from China and America, as well as according to UK Parkinson's Society Brain Bank Clinical Diagnostic Criteria.And statistic analyses included linear trend test and logistic regression.

  Results   The result of logistic regression showed hypertension was associated with the incidence of clinically probable P Din the population aged over 55 years.RR=1.648(1.147-2.368).When the relation was adjusted by some possible confounding factors, such as age, gender, smoking, drinking, it still existed.Then data were analyzed by different gender.For males, hypertension was not significantly associated with the incidence of clinically probable PD.But for females, hypertension was remarkably associated with the incidence of PPD.RR=2.347(1.347-4.091).And the relation was adjusted by the possible confounding factors, it still existed.RR values increased with the blood pressure increase(Trend test, χ²=11.325, P=0.003)which indicated that there was a dose-response relationship between blood pressure and PPD.

  Conclusion   Hypertension was one of the risk factors for PPD in the female residents older than 55 in Linxian county, and the incidence risk for PPD increased as BP increased.