Regulation of zinc, selenium, chromium on disorders of blood glucose and lipid metabolism in diabetic rats

  Objective   To study the effects of zinc, selenium, chromium on glucose and lipid metabolism in diabetic rats, and its related biochemical mechanism.

  Methods   12 rats were randomly selected from 52 male Wistar rats as normal control group(NC group).The rest induced by alloxan into diabetic model were randomly divided into diabetic control group(DM group)treated with water and three other experimental groups(DM+Zn group, DM+Se group, DM+Cr group)supplemented with zinc, selenium, chromium respectively by gavage daily for 60 days.At the end of the treatment, the blood biochemical analysis, pancreatic islets morphological observation were performed.

  Results   Zinc, selenium, chromium could partially improve the disorders of glucose and lipid metabolism of diabetic rats.The effects of zinc and selenium supplement were much better than those of chromium supplement.Zinc, selenium could increase the antioxidant activity and alleviate pathological damage of pancreatic islets in diabetic rats, there was no change in DM+Cr group.

  Conclusion   Zinc, selenium, chromium could improve the disorders of glucose and lipid metabolism in varying degrees by different ways.