Objective To study the protective effects of d-penicillamine and sodium 2, 3-dimercato-1-propanesulfonate on attenuating nephrotoxicity towards rats exposed to mercuric chloride(Hg).
Methods 32 Wistar rats were divided into 4 groups.The rats in the first and second groups were respectively subcutaneously(sc.)injected with 0.9% saline and 2.5 mg/kg mercuric chloride, the rats in the third and fourth groups were pretreated with DPA and DMPS respectively at the dose of 200μmol/kg and after 2 h the rats were sc.injected with 2.5 mg/kg Hg.24-hour urine samples were determined for NAG, ALP activities and urinary protein levels.After 48-hour administration the BUN, MDA, GSH and GSH-Px levels were determined.
Results DMPS and DPA reduced significantly urinary NAG, ALP activities, urinary proteins and BUN contents, and Hg contents in the kidneys and livers, however there was not any influence on urinary and renal Hg contents.
Conclusion DMPS attenuated the damage of Hg in the kidney more efficiently than DPA.
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