Study on relationship between GSTM1 polymorphism, diet factors and lung cancer

  Objective   To study the relationship of polymorphism of GSTM1 and diet factors with lung cancer risk in Guangzhou.

  Methods   A case-control study which included 58 cases of lung cancer and 62 controls was conducted.All subjects were investigated with a uniform questionaire.The genotypes of GSTM1 were detected by PCR.

  Results   There was no significant association between the genotypes of GSTM1 and the risk of lung cancer(OR 1.73, 95%CI 0.84-3.58);The consumption of carrot was significant inversely correlated with the risk of lung cancer(OR 0.24, 95%CI 0.10-0.58).Cooking with animal oil was negatively and significantly associated with the risk of lung cancer(OR 5.34, 95%CI 1.1320.16).There was significant association between lung cancer and the consumption of carrot(OR 3.53, 95%CI 1.2413.03)after multivariable-adjusted logistic regression model.

  Conclusion   There was not significant association between the polymorphism of GSTM1 and the risk of lung cancer.Cooking with animal oil significantly increased the risk of lung cancer.Consumption of carrot significantly reduced the risk of lung cancer.A combined effect of polymorphism of GSTM1 and consumption of carrot on the risk of lung cancer was suggested.