Epidemiological study on AGT polymorphism of essential hypertension

  Objective   To analyse the correlation between polymorphism of the angiotensiogen gene, environment factors, and essential blood hyper tension.

  Methods   To observe the blood pressure of the patients with essential hypertension patients in west of Anhui. Polymerase chain reaction (PCR) combined with restrictive fragment length polymorphism (RFLP) were used to detect genetype frequency and polymorphism for angiotensiogen gene (A-20C).

  Results   The frequency of allele C and A accounted for 15.3% and 84.7% in the total populations. Through chi-square test, it meeted with H-W balance (χ²=0.58, P > 0.05). The linear regession of AGT genetype type with the baseline blood pressure value showed that SBP of the mutation type (AC+CC) group were higher than AA group (P < 0.05), especially in female through linear Logistic regression (P < 0.05).

  Conclusion   It was the first time in China to report the AGT (A-20C) gene polymorphism and genetype frequency. High blood pressure was chiefly show ed SBP increase for the total population with mutation type (AC+CC), especially among female.