Effect of smoking on endocrine gland function of female and related factors

  Objective   To understand the influence of smoking on feminine endocrineg land function and the micro element metabolism and the oxidizing function.

  Methods   To collect punctately the urine and blood of women whose ages ranged from 30 to 40, who lived in some north suburb continually over 5 years and smoked over 2 years and did not take or ally the contraceptive drug, to test the volume of thyroid and FT₄, FT₃, TSH and estradiol(E₂), etc.

  Results   The FT₄ and E₂ of the smoking women were 10.9% and 13.6% lower(P_ar < 0.05)than the control group respectively.The FT₃ and TSH increased 74.4%(P < 0.01)and 10.9%(P < 0.05);the iodine and GPx and selenium decreased 11.6%(P < 0.05)and 15.7% and 22.4%(P_ar < 0.01);the lead and cadmium and LPO increased 25.4% and 160.2% and 31.1%(Par < 0.01); the value of r of the lead iodine and selenium were-0.683 and-0.537(P_ar < 0.01)respectively; the value ofr of selenium and FT₃ and GPx were-0.688 and-0.546(P_ar < 0.01)respectively; the value of r of the LPO and E₂ were-0.446 and (P < 0.05)and-0.659(P < 0.01).

  Conclusion   Smoking could interfere the coordination of the feminine endocrine gland function, which was concerned with the free radical caused by the poison and the inhibition against the absorption of micronutrient.