Distribution of beta 3-adrenergic receptor Trp64Arg mutation in school-aged children

  Objective   To learn the distribution feature of beta 3-adrenergic receptor β(₃-AR)Trp64Arg mutation in school-aged children in Nanjing and its relationship with childhood obesity.

  Methods   β₃-AR Trp64Arg mutation was detected with the method of RFL P among 177 school children, their height and weight were measured.

  Results   The mutative C allee was 0.24 for all the children, 0.226 for boys and 0.267 for girls.The frequency of C allee and the genotype Trp64Arg was higher in obese girls.The frequency of the genotype Trp64Arg was 70.3%, 71.4% for obese girls with obese parents or obese mothers.Body weight and BMI of the children with β₃-AR Trp64Arg mutation were also higher.The risk for obesity in girls with β₃-AR Trp64Arg mutation was 4.5.

  Conclusion   There was distribution of β₃-AR Trp64Arg mutation in school-aged children in Nanjing, especially in obese girls.It may be related to obesity.