Cross-resistant adapting response induced by radiation and mitomycin C

  Objective   To probe the laws of the cross-adapting response induced by low dose radiation and low concentration mitomycin C.

  Methods   The human lymphocytes, bone marrow cells of mice were treated by low dose X-ray or low concentration mitomycin C before treated by high dose X-ray or high concentration mitomycin C.Some targets were observed, such as chromosome aberration of human lymphocytes, bone marrow cells of mice, micronuclear(MN), sister chromatied exchange(SCE).

  Results   The targets of above all appeared cross-adapt response.

  Conclusion   Cross-adapt response can be inducd by low dose radiation or by low concentration mitomycin C not only in vivo but also in vitro.