Antagonistic effects of selenium on fluoride-induced lipid peroxide in rats

  Objective   To study the relation between fluorine and lipid peroxide, and the effects of selenium of fluor ideinduced lipid peroxide.

  Methods   40 rats were divided into four groups(control, fluorine, selenium, Se-fluorine by drinking) in random and fed for eight weeks.To observe the effects of selenium of fluoride-induced lipid peroxide in blood serum, liver, kidney, heart, testis in rats.

  Results   the glutathione peroxidase(GSH-Px)in whole blood of the fluorine group was significant decrease, and the obvious increase of lipid peroxide(LPO)levels in blood serum, liver, kidney, heart, testis can be observed.Adding the selnium in drinking can increase the power of anti-oxidation, as well as increase the activities of GSH-Px and decrease the levels of LPO.

  Conclusion   Selenium can antagon fluoride-induced lipid peroxide.