Distribution of SDF 1-3' A, CCR2-64I and-2518MCP-1 polymorphism in population

  Objective   To investigate the distribution of SDF1-3'A, CCR2-64I and-2518MCP-1 polymorphism in the indigenous Han population of Anhui province.

  Methods   the polymorphism of SDF1-3'A, CCR2-64I and-2518MCP-1 was dete rmined by PCR-RFLP and ARMS(amplification refractory mutation system)respectively.

  Results   the frequency of-2518MPC-1Gin Anhui Han Amerians(P < 0.01).There was significant difference in frequency of CCR2-64I between Caucasian and African Amerians and Anhui Han population(25%), and the frequency of SDF1-3'A (22%)in Anhui Han population was higher than that of African Amerians.But there was no significant difference between Anhui Han population and others areas in China.

  Conclusion   the frequency of-2518MCP-1, CCR2-64I and SDF1-3'A in Anhui Han population was different from others population in the world.