Study on mechanism of purslane on anti-aorta foam cells forming

  Objective   To explore the mechanism of purslane on anti-aorta foam cells forming and to study various factors in affecting AS forming.

  Methods   Rabbits were divided into 4 groups.The model of hyperlipidemia was established in A, B, C groups.B, C groups were given 8 or 12 gram purslane every day to each animal for 11 weeks.Blood lipids, molondiadehyde(MDA)and blood viscosity were determined.Aor at intima pathological changes under the electronmicroscope was observed.Stepwise regr ession was used to siev e primary factor in affecting of AS forming.

  Results   Serum cholesterol(TC), triglyleride(TG), MDA, whole blood and plasma viscosities in B, C groups were markedly decreased compared to A group(P < 0.01);buthDL-C was obviously increased(P < 0.01).TC, whole blood viscosity in C group were significantly lower compared with B group(P < 0.01).

  Conclusion   Purslane powder could markedly restrain or lower TC, TG, MAD, whole blood and plasma viscosity; but raise HDL-C.Accompany ing dose increase, puslane effect was increased.It was proved under the observation of electronmicroscope that purslane could decrease lipids deposition of arotoaintima and inhibit the formation of ather osclerotic plagul.Multiple stepwise regression analysis suggested that TC and plasma viscosity were primary factors in influence of AS forming.Purslane can markedly decreased TC and plasma viscosity.