Study on interaction between apolipoprotein E polymorphism and enviro nmental factors for coronary heart disease

  Objective   To explore the risk fators of coronary heart disease and the interactive effects between ApoE polymorphism and the other risk factors.

  Methods   90 patients with CHD and 90 control subjects without symptoms and sign of CHD was studied, on the base of logistic regression, odds ratios(OR)and interactions between ApoE polymorphism and other risk factors of coronary heart disease were analyzed.

  Results   the results of multivariable logistic regression showed thathy-pertension, hyperlipemia, Cpn infection, CMV infection and ApoE polymorphism were risk factors of coronary heart disease, odds ratios of the risk factors in coronary heart disease were 5.04, 3.64, 2.37, 3.51 and 3.33 respectively.The interaction indexs were 1173, 1155, 1128 and 1120.The attributable proportions were 40.64%, 33.25%, 19.01% and 15.15%.

  Conclusion   Hypertension, hyperlipemia, Cpn infection, CMV infection and ApoE polymorphism played important roles in the development of coronary heart disease, and ApoE plused any one of the following factors, such as hypertension, hyperlipemia, Cpninfection, CMV infection, which could increase the risk of coronary heart disease.