Inhibitory effect of extract from dictyophora on micronucleusmice induced by cytophosphane

  Objective   To observe antimutagenic effect of the extract from dictyophora, and to provide evidences to further develop and utilize it.

  Methods   By using micronucleus test, the resisting effect of the extract from dictyophora to micronucleus mutation of the polychromatice rythrocyte of mice marrow in sternum and os femoris caused by cytophosphane was studied.

  Results   the extract from dictyophora dosage of 2.5, 5.0, 10.0 g/kg had the obvious resisting effect on the increase of mice marrow in sternum and os femoris micronucleus caused by cytophosphane(P < 0.001).It also showed that these effects had well dose-response dependent relationship.The relative coefficient was-0.98.

  Conclusion   the extract from dictyophora had the effect of anti-mutation.