Effects of fluoride on bone morphogenetic protein expression in oste oblast

  Objective   To discuss whether the heterotopic ossification in skeletal fluorosis caused by fluor ide affects the expression of bone morphogenetic proteins.

  Methods   To observe the effects of different concentrations fluoride on the features, proliferation of osteoblast, alkalline phosphatase activity and the expression of bone morphogenetic proteins in cultured sucking miceosteoblasts.

  Results   Lower concentration fluoride(10^-5 mol/L)can promote the proliferation and ALP activity in osteoblast, but have no significant effects on BMP expression; higher concentration fluoride(10^-5 mol/L)can promote significantly expression of BMP.

  Conclusion   High dose fluoride can promote the expression of BMP in sucking mice osteoblast.