Case-control study of conditional logistic regression on risk factors of perinatals' birth defects

  Objective   To explore the risk fctors for the occurrence of the perinatals birth defects in Guangxi province and plan some intervention measures.

  Methods   Using conditional logistic regression to analyse environmental risk factors which 276 pairs perinatals'(pairmatching case-control)parents were exposed to in Guangxi province in the year 2000.

  Results   Statistically significant(α< 0.05)risk factors were: maternal pesticide exposure during pregnancy(OR=5.764), maternal malnutrition during pregnancy(OR=4.595), paternal chemicals exposure(OR=2.505), maternal chemicals during pregnancy(OR=2.331), meternal parity more than twice(OR=1.934), maternal overloaded physical labor during pregnancy(OR=1.480), maternal unhealthy feelings during pregnancy(OR=1.460), which seemed relevant to the occurrence of the birth defects.

  Conclusion   Birth defects can be intervened in the respects such as vocational factors, nutritional factors and psychological factors in Guangxi.