Antimutagenicity of curcumin on accumulatants in mainstream of cigarette smoke

  Objective   To observe the antimutagenicity and filter effect of the main mutagens in mainstream of cigarette smoke by adding curcumin in the filter.

  Methods   The accumulatants of the mainstream of cigarette smoke were collected by eight tunnel manipulated autosmoking machine.The mutagenicity and the main mutagens were tested by Ames test, RPHPLC methods in two groups added curcumin or not in the filter.

  Results   The positive mutagenicity was found in all samples of the noncurcumin group.A significantly diminished mutagenicity and decreased BaP, Tar, TPM, and nicotine level were observed while adding curcumin in the filter, especially at the concentration of 2.4 mg/ml.

  Conclusion   The mutag enicity of the accumulatants in the mainstream of cigarette smoke can be decreased effectively and the BaP, Tar, TPM, and nicotine level can also be lowed by adding curcumin in the filter.