Study on relationship between ANP and RAA system in rat carried rapidly into plateau

  Objective   To study the changes of artrial natriurctic factor and renin-angiotension-aldosteron and their relationship when an organism got to the area with high elevation rapidly.

  Methods   Thirty rats were carried rapidly from Qingdao(with an elevation of 10 m)to Xining(2 261 m)and Tianjun(3 800 m).Plasma ANP and rennin, angiotensin Ⅱ aldoster one activities were dynamically tested.

  Results   When rats were carried into plateaus rapidly, their plasma ANP concentrations increased significantly(P < 0.01), concentr ations of renin an angiotensin Ⅱ increased, and the plasma aldosterone concentrations decreased.

  Conclusion   Bioctive substances had important physiological effects on rapid adaptation of organisms to the plateau environment.