Experimental research on damage effect of air pollutants on deeper respiratory tract of rat

  Objective   To inquire into the mechanism of air pollutants to respiratory inflammation.

  Methods   Rats with 180-220 g weight were randomly divided into 4 groups, which were control group, lower, middle and higher dose groups.Rats of dose groups were separately poured into 7.5, 15 and 30mg pollutants by upper respiratory tract and exposed to SO₂, NO₂ of 8, 5;16, 10, 32, 20mg/m³ for seven days.On the first day and eighth day after contaminated, ACP, AKP, SA, LDH, CP, whole proteins and white proteins in serum, and ACP, AKP, SA, LDH, whole proteins in BALF were measured.

  Results   On the first day after exposed pollut ants.AKP, SA, CP in serum of higher dose rats were increased and higher than that of control rats.There was significant difference(P < 0.05).SA, LDH and whole proteins in BALF showed increasing and higher than that of control group.Especially LDH, whole proteins still were in high level at the eighth day.On the eighth day after exposed pollutants, SA, CP, white proteins in serum of higher dose rats were also higher than that of control rats(P < 0.05).

  Conclusion   Air pollutants could impair bronchoalvellar lavage membrane and damage respiratory tract and pulmonary, which lead to the change of biochemical indicators and respiratory disease.