Effects of alcoholism on lipid peroxidation and antioxdation of rabbits

  Objective   To investigate the changes and characteristics of rabbit's lipid per oxidation and antioxdation system induced by alcoholism.

  Methods   To make rabbits alcoholism by using the wine containing 50% of alcohol at dosage of 8 ml/kg·d by pouring into stomach with a plastic tube for 6 months and to observe the changes of the serum super oxide dismutase(SOD), malondialdehyde(MDA), antio xidant ability(AOA)in 4, 12 h and 1-6 months.

  Results   After pouring 4 hours, the AOA and SOD activity reduced, MDA increased remarkably.Then after 24 hours and in 1-2 months AOA, SOD and MDA did not change significantly.In 3-6 months, AOA and SOD activity decreased, MDA increased in 4-6 month gradually ag ain.

  Conclusion   Shortter mex cessive intake of wine can remain compensation ability for antioxidation, though may lead to peroxidation and decreaseant oxidation ability, ot herwise, long-ther mexcessive may induce the deficiency of compensation ability for antioxidation.