Objective To study effect of cadmium chloride on physiological function of male reproductive system.
Methods Microelement levels in semen were analysed for male workers exposed to cadmium.40 mice were divided into 4 groups: cadmium chloride 3.5, 7.0, 14.0 mg/kg experimental groups and the control group.They were administrated through the stomachs.The ultrastucture in testis, DNA level in testis cells, microelement levels in testis were observed with occupational epidemiologic investigation and animal experiment.
Results Cadmium levels in semen of male workers exposed to cadmium were higher than the control group(P < 0.01).Cadmium level in testis were higher(P < 0.05).Ultrastucture in testis converted.DNA level of single cell was lower(P < 0.01).
Conclusion Cadmium chloride affected physiological function of male reproductive system, lowered genitality.
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