Study on anti-oxidative action on tissues of mice

  Objective   To study the anti-oxidative action of PVA on the tissues of mice.

  Methods   Contents of malon-dialdehyde(MDA), superoxide dismutase(SOD)and lipofuscin in the heart, liver, brain and kidney of mice were measured using TBA, NBT and fluor escent technique respectively.

  Results   PVA(200, 400 mg/kg·d 30 d)could decrease significantly the content of MDA and the content of lipofuscin in all tissues(P < 0.05).PV A(400 mg/kg·d 30 d)could increase significantly the activity of SOD and decrease significantly the content of lipofuscin and MDA in heart, brain of mice.

  Conclusion   PVA could increase the anti-oxidative action in vivo significantly and prevent lipid peroxidation damages in tissues.