Effects of oxidative stress on rat's hepatic damage caused by subchronic fluorosis

  Objective   To study the effect of oxidative stress on rat's hepatic damage caused by subchronic fluorosis.

  Methods   Rats were given 0, 50, 100, 150 mg/L sodium fluoride in distilled water drinking for three months.The contents of malonyl dialdehyde(MDA), metabolic product of lipid peroxidation and activities antioxidases in fluoride-exposed rat liver were determined.Meanwhile the activities of serum SGPT, SGO T were studied.

  Results   The contents of malonyl dialdehyde(MDA)in rats liver in group of 150 mg/L were significantly higher than control group.The activities of SOD in 100 and 150 mg/L groups were significantly lower than control group and the activities of GSH-Px tended to decrease with the increase of fluoride content in drinking water.The activities of SGPT in 150 mg/L groups were significantly higher than control group.The activities of SGPT in 100 and 150 mg/L groups were significantly higher than control group.There was a significantly positive correlation between MDA and SGPT(r=0.460, P=0.007).

  Conclusion   The balance of oxidative system and anti-oxidative system in rat's liver with fluorosis was broken.The oxidative damage caused by oxidative stress may be the important reason for fluoride-induced hepatic toxicity.