Objective To sutdy the cause and effect relation between TGFβ1、EGF、P53、PCNA and prostatic cancer.Samples came from surgical operation and tissues biopsy.
Methods Thirty-six patients with prostatic cancer were analyzed and explored by immunohistochemistry.
Results It was stronger positive(> 80%)for the cell nucleus and cell thick liquid of cancer cell as well as surrounding matrix in prostatic cancer tissues.Expression of P53 in prostatic cancer tissues was also observed with antibodies against them.Positive stain of P53 was found both in nuclei and cytoplasm of epithelium cells in prostatic cancer tissues.Innumoposit ive stain of PCNA was presented in prostatic cancer cell(> 60%).
Conclusion Mutation of P53 occurred in prostatic cancer tissues and reflected actively proliferative capacity and status of cancer cells.
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