Objective To clarify the feasibility of seleniumag ainstarsenic-induced blood lipids changes in rat and its dose range characteristics.
Methods The rats were randomly divided into control, arsenic, selenium, arsenic and selenium in combination, respetively.A fter various treatments, the blood lipids were determined.
Results In comparison with the levels of total cholesterol(TC), trig lyceride(TG)and high-density lipoprotein(HDL)in control group, there was a significant decrease in TC and TG and arise in HDL in 1/5 LD50 arsenic group.Relative to those in 1/5 LD50 arsenic group, there was a significant difference in TG in 1/5 LD50 As and 1/160 LD50 Se group(P < 0.05), TC and TG in 1/5 LD50 As and 1/120 LD50 Se group(P < 0105).TC, TG and HDL in 1/5 LD50 As and 1/80 LD50 Se group(P < 0.05), respectively.
Conclusion Arsenic could induce a change in blood lipids spectrum in rat and that selenium could combatagainst this change.1/80 LD50 Se might be the optimal dose for the effect.