Antagonistic effect of selenium on arsenic-induced changes in blood lipids spectrum in rat

  Objective   To clarify the feasibility of seleniumag ainstarsenic-induced blood lipids changes in rat and its dose range characteristics.

  Methods   The rats were randomly divided into control, arsenic, selenium, arsenic and selenium in combination, respetively.A fter various treatments, the blood lipids were determined.

  Results   In comparison with the levels of total cholesterol(TC), trig lyceride(TG)and high-density lipoprotein(HDL)in control group, there was a significant decrease in TC and TG and arise in HDL in 1/5 LD₅₀ arsenic group.Relative to those in 1/5 LD₅₀ arsenic group, there was a significant difference in TG in 1/5 LD₅₀ As and 1/160 LD₅₀ Se group(P < 0.05), TC and TG in 1/5 LD₅₀ As and 1/120 LD₅₀ Se group(P < 0105).TC, TG and HDL in 1/5 LD₅₀ As and 1/80 LD₅₀ Se group(P < 0.05), respectively.

  Conclusion   Arsenic could induce a change in blood lipids spectrum in rat and that selenium could combatagainst this change.1/80 LD₅₀ Se might be the optimal dose for the effect.