Study on antimutangenic and antineoplastic effect of ganoderma lucidum spore powder

  Objective   The antimutangenic and antineoplastic effects of ganoderma lucidum spore powder were studied to provide scientific basis for exploiting health function of ganoderma spore power.

  Methods   Antimutangenic effect of ganoderma lucidum spore powder was testified based on the mice bone marrow cell micronuclei test and the mice testis chromosome aberration; Antimutangenic effect of ganoderma lucidum spore powder was testified based on S-180 and H-22 tumor cell transplanting test.

  Results   The micronuclei frequency induced by cyclophosphamidum in mouse bone marrow cells and chromosome aberration frequency induced by mitomycinc were both inhibited significantly by ganoderma lucidum spore powder.

  Conclusion   Ganoderma lucidum spore powder had preventive effects on DNA damage in body cell and germinal cell, and had a inhibitory effect on tumor growth.