Genotic Analysis of Wild Type Measles Viruses Circulating inIiaoning Henan Hebei Provinces of China During 1995-1997

To inves tigate the molecular epidem iology of measles virus (MV) in china sequences analysis of MV was performed based on a 282-nt region of the nucoprotein (N)gene and a 450 ntregion of the hewn aglutinin(H)gene by dmect sequencing of RT-PCR an plicnobtamed from clinical specimens The results revealed that one MV strain belongs to ED-like genotype and ran ainder strains were clustered in to a newgenotype which was distinct from Chinese vaccine strains and MV trains previously de scribed circulating in other countries and represented a new genotype T here was up to 15.4% divergence in the nt282N gene and 10.8% divergence in the nt450h gene between the new genotype and other genotypes.