An Experimental Study on the Toxic Liver and Renal Damage Induced by Chromium

Male wistar rate were injected intraperitoneally with potassium dichromate(7.35mg/kg body weight),one time a day for a week,and continue to be observed for seven days after stopping chromium treatment.The results showed that apparent changes of morphology and function on the kidney and liver exhibited in sucession.The intensity and range of the pathological changes increased with exposure time.The renal damage was chracterized by the renal tubular failure,the glomeruli were lnsulted in later exposure period.The feature of the hepatic injuries was cloudy swelling degeneration and spot necrosis of the liver cell around central vein areas,the activities of AST and ALT in serum were higher significantly than those in the control group.The renal functions were slowly and inocmpletely recovered,but the liver functions gradually restored to normal level in a week after creasing chromium injection.These datum suggested that the extent of renal injuries was more serious than that of the liver in Chromium exposure rat,and the selfrepairable ability of the liver was stronger than that of the kidney.