Abstract: ObjectiveTo investigate the levels of cord plasma adiponectin in large for gestational age infants and to explore its clinical significance.MethodsIn the present study,30 LGA infants and 30 appropriate AGA infants were enrolled in.Puerper a and cord plasma adiponectin was determined with ELISA.Blood lipids were assayed with turbidimetry.The correlation between cord plasma adiponectin and puer pera plasma adipo nectin,maternal plasma adiponectin,newborn gender, birth weight,BMI,placental weight and blood lipids were analyzed.Results (1)Compared with AGA group,cord plasma adiponectin in LGAinfants decreased significantly(P<0.01),and blood lipids change slightly(P>0.05).(2)The adiponectin in L GAinfants inversely correlated with birth weight,new born BMI,placental weight and the cord blood TG levels(r=-0.848,-0.785,-0.835,all P<0.001).(3)Adiponectin and lipid components in cord blood have no difference between male and female neonates(P>0.05).ConclusionAlteration in plasma adiponectin correlated with LGA infants.It may apply to estimate the developing of LGA infants.