广东省2021年诺如病毒感染疫情流行病学特征分析

李彩霞; 梁玉凤; 徐静; 张昌; 曾汉日; 龙勇; 柯碧霞

doi:10.11847/zgggws1138942

广东省2021年诺如病毒感染疫情流行病学特征分析

doi: 10.11847/zgggws1138942

李彩霞¹,
梁玉凤^{1, 2},
徐静¹,
张昌¹,
曾汉日¹,
龙勇¹,
柯碧霞^1, ,

1.
广东省疾病预防控制中心广东新发突发传染病防治工作站，广州 511430
2.
南方医科大学公共卫生学院

基金项目: 广东省省级科技计划项目（2019B030316013）

详细信息

作者简介:
李彩霞（1982 – ），女，广东广州人，博士，研究方向：诺如病毒及肠道病毒的致病机制

通信作者:
柯碧霞，E-mail：2212935520@qq.com

中图分类号: R 511
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出版历程
- 接收日期: 2022-04-25
- 网络出版日期: 2022-11-24
- 刊出日期: 2022-11-30

Prevalence and genetic characteristics of norovirus epidemics in Guangdong province, 2021

1.
Guangdong Workstation for Emerging Infectious Disease Control and Prevention, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, Guangdong Province 510515, China

摘要

摘要: 目的分析2021年广东省诺如病毒聚集性或暴发疫情的流行病学特征。方法收集广东省2021年1 — 12月诺如病毒感染疫情样本及相关基本信息，通过实时荧光定量PCR（qRT-PCR）对样本进行诺如病毒的鉴定，筛选诺如病毒GI型和GII型阳性样本，通过PCR扩增、建库、测序、序列拼接后对其进行基因分型。结果 2021年广东省共报告141起诺如病毒感染疫情，其中92.91 %（131起）的疫情发生在托幼机构或学校；疫情的流行季节为冬春季。73起疫情（51.77 %）确定了基因分型。94.52 %（133起）的诺如病毒感染疫情由GII型引起，其中GII.2[P16]和GII.4[P31]分别占比39.13 % 和23.19 %。结论广东省2021年诺如病毒疫情主要发生在托幼机构和学校，GII.2[P16]和GII.4[P31]分别是春季和冬季的主要流行型别，仍需继续加强诺如病毒疫情监测以及分子分型研究。
- 诺如病毒 /
- 疫情 /
- 基因型 /
- 流行病学特征
Abstract: Objective To analyze prevalence and genetic characteristics of clusterings/outbreaks of norovirus (NV) infection in Guangdong province in 2021. Methods We collected the information on all laboratory confirmed NV infection clusterings (3 correlated cases in 3 days at a venue) and outbreaks (20 correlated cases in 7 days at a venue) reported in Guangdong province throughout 2021. Anal swab/stool specimens of the reported cases were sampled for NV detection with quantitative real-time PCR (qRT-PCR). The NV GI and GII strains screened out from positive specimens were genotyped with PCR amplification, library preparation, gene sequencing and splicing. Results Of a total of 141 NV clusterings/outbreaks reported in the province during the year, 92.91% occurred in nurseries or schools and mainly during winter and spring seasons. For the genotyped NV strains isolated from specimens of 73 outbreaks (51.77% of all epidemics), 94.52% were NV GII, with GII.2[P16] and GII.4[P31] accounting for 39.13% and 23.19% of all NV strains, respectively. Conclusion In Guangdong province during 2021, the norovirus clusterings/outbreaks occurred mainly in nurseries and schools in winter/spring seasons and the majority of the outbreaks were caused by norovirus GII.2[P16] and GII.4[P31].
- norovirus /
- epidemic /
- genotype /
- epidemiological characteristics

HTML全文

图 1 2021年广东省不同月份NV疫情相关基因型分布

下载: 全尺寸图片幻灯片

表 1 2021年广东省NV疫情发生场所与NV基因型分布

基因型	疫情发生场所（起）							合计
基因型	托幼机构	中小学	职业技术学院	大学	集体单位	社区及家庭	酒店	合计
GII.2[P16]	10	15	0	0	2	0	0	27
GII.3[P12]	1	2	1	0	0	0	0	4
GII.4[P16]	2	0	0	0	1	0	0	3
GII.17[P17]	2	7	1	0	1	0	1	12
GII.8[P8]	1	1	0	0	0	0	0	2
GII.6[P7]	1	3	0	1	0	0	0	5
GII.4[P31]	14	1	0	1	0	0	0	16
GI.6[P11]	0	1	1	0	0	0	0	2
GI.4[P4]	0	1	0	0	0	0	0	1
混合基因型	0	0	0	1	0	0	0	1
未知基因型	30	28	2	3	3	2	0	68
合计	61	59	5	6	7	2	1	141

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