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1999 Vol. 15, No. 10

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Study on Transmission of Hemorrhagic Fever with Renal Syndrome Virus Among Experimental Animals by Aerosol
Zhang Yun
1999, 15(10): 865-866.
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The study results show that the filtrate of soaking from small pieces of cloth, scrap of paper or straw, polluted by blood, urine and faeces of mice with HFRSV antigen positive could infect suckling mice under the condition of pH6.5~7.5,4℃~15℃ for 28h.HFRSV antigen could be detected in lung after absorbedHFRSV aerosol labeled with fluorescein for 5 min, and 95% of HFRSV retained in the respiratory tract, and antigen of HFRSV could be detected in pulmonary phagocytes and PBMC after inhaling aerosol for 5 days, and HFRSV-RNA could be amplificated by RT-PCR from heart, lung ,liver and spleen of mice absorbed aerosol for 10 days. HFRSV aerosol was absorbed into blood and engulved by phagocytie system after being inhaled . It took about 10 days for total transportation and elimination by urine. Through mice field research, we found that 15 days after infection, the antigen of HFRSV was detected from the experimental animals and from the control group also, and two strains of HFRSV were isolated from aerosol in the room of experimental animals.
1999, 15(10): 866-866.
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The Experimental Study on the Antitumor Effects of Ascorbic Acid in Vitro
Yang Lin
1999, 15(10): 867-868.
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An external culture of three human cancer cells were used to study the effect of Ascorbic Acid(Vc) on the multiplication,the survival,and the content of living cell protein of cells.Human hepatic carcinoma cell line(Q3),human throat carcinoma cell line(HEP-2) and human gastric carcinoma cell line(SGC) were studed with technique of cell cultrue.The results showed that the different concentratrations of ascorbic acid inhibite carcinoma cell lines growth differently.The resuls also suggested that a proper use of ascorbic acid might be beneficial in the prevention of and might act as an adjuvant treatment of human cancer.
An Experimental Study on the Toxic Liver and Renal Damage Induced by Chromium
Zeng Ming
1999, 15(10): 869-870.
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Male wistar rate were injected intraperitoneally with potassium dichromate(7.35mg/kg body weight),one time a day for a week,and continue to be observed for seven days after stopping chromium treatment.The results showed that apparent changes of morphology and function on the kidney and liver exhibited in sucession.The intensity and range of the pathological changes increased with exposure time.The renal damage was chracterized by the renal tubular failure,the glomeruli were lnsulted in later exposure period.The feature of the hepatic injuries was cloudy swelling degeneration and spot necrosis of the liver cell around central vein areas,the activities of AST and ALT in serum were higher significantly than those in the control group.The renal functions were slowly and inocmpletely recovered,but the liver functions gradually restored to normal level in a week after creasing chromium injection.These datum suggested that the extent of renal injuries was more serious than that of the liver in Chromium exposure rat,and the selfrepairable ability of the liver was stronger than that of the kidney.
Effect of Vitamin K and Calcium on Bone Metabolism of Ovariectomized Rat
Zhao Xinhua
1999, 15(10): 871-873.
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Ovariectomy has a proven pronounced effect on osteoporosis.In the present study ,ovariectomized felmal Wistar rate(170±15g) were treated with vitamin Kor/and calcium for 6 months,in order to study the effect of vitaminK or/and calcium supplementation on the prevention of osteoporosis.VitaminK(90mg/kg) or/and calcium(5g/kg)were added to the regular diet(Vk50μg/kg,Ca5g/kg).The findings were as follows:Vitamin K supplementaton reduced urinary calcium and hydroxyproline excretion,suggesting a decrease in bone resorption;At the same time,vitamin K elevated the circulating levels of osteocalcin and OC bound,suggesting an incrdease in bone mineralization.And more,the effect of vitamin K combined with calcium on the prevention of osteoporsis is stronger than that of vitamin K or calcium solely.The present study indicated that postmenopausa women,as a risk popular of osteoporosis,should increase their their intakes of vitamin K and calcium.Vitamin K may be used as a pharmacology to prevent and cure osteoporosis.
1999, 15(10): 874-875.
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1999, 15(10): 875-875.
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The Study of Reproductive and Developmental Toxicity of Arsenide
Yao Hua
1999, 15(10): 876-877.
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In order to investigate the reproductive and developmetal toxicity of arsenide,the method of two generaition one nest reproductive test was used in this study.The result showed that(1)The pregnant rate and feeding survival rate in high dose grope were lower than those of in the control and low dose group.(2)After 10、20、30days of birth,the weight of offspring in high dose group were lighter than that of the groups of control and low dose.(3)The contents of arsenic in rats soffspring were increased by dose of arsenic and the differences were significant.(4)The spleen/weight and thymus/weight ratios in high dose group were lower than the control.Hb,TLC,clearance index and phagocytic index reduced obviously.This study suggested that arsenic can affect the ability of animal's reproduction and development,pass through the placenta barrier and result in affecting growth,development and phsiological and function of offspring.
1999, 15(10): 878-878.
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1999, 15(10): 879-879.
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1999, 15(10): 880-880.
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Twinning and Cerebral Palsy
Liu Jian-meng, Li Song, Lin Qing, Li Zhu
1999, 15(10): 881-883.
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A cross sectional survey was carried out among children aged under 7 years in seven cities of Jiangsu province in order to obtain the prevalence of cerebral palsy and to explore the association between twinning and cerebral palsy. The prevalence of childhood cerebral palsy in twins was 9.74‰(95% confidence interval 6 15‰ to 13 33‰),being 6.4 times that in singletons (95% confidence inteval, 4.4~9.3). When stratified by birthweight, the prevalence of CP in twins with low birth weight was lower than that in singletons at the same biHh weight group. In contrast, in normal birth weight category twins had a higher prevalence of CP than singletons. When stratified by standard deviate, the prevalence of CP in twins was uniformly bigber that in singletons in all strata and the risk of CP for twins appeared to be rising as the birth weight increased. The results suggested that twinning was an independent risk factor of CP in all birthweight groups and the risk of CP started to rise as fetus matured.
1999, 15(10): 883-883.
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The Study of Color Vision in Women Exposed to Carbon Disulfide by FM100 HUE
Wang Chunhong
1999, 15(10): 884-885.
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To explore color vision effect on CS 2 exposed workers,the color discrimination of 70 exposed and 23 nonexposed women was studied by the Farnsworth Munsell 100 HUE test(FM100 HUE).The concentration of CS 2,determined by Multi gas Monitor Type 1320,in workplace was 12.5~36 4mg/m 3.The results showed:the FM100 HUE color vision score did not occurred significantly more often in the exposed group(84.5)than that of among the referents(65.2),but the discrimination to the green zone was impaired significantly(P0 01).The results suggested that the color vision was disturbed among workers exposed to CS 2.
1999, 15(10): 885-885.
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Study of Clinical Epidemiology on Children's Infectious diseaae caused by MP with IFA
Chen Lian
1999, 15(10): 886-886,887.
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case with respiratory tract infection and penumonia as well as 76 health children's serum were tested by MPIFA which was from American zeus scientific Inc. Results show that positive rate of MPIgM, IgG in respiratory tract infection was 23% and l3% res pectively, both positive rate is 6.0%,total positive rate was 30%;positive rate of MPIgG in Health children was 5.22%. The infomtation of 25 MP identited by laboratory and clinic in hospital was analyzed.The aystem were various. 80% of case had persistent cough, 48% had fever, the white blood cell in most case were in nomal level.72% case had pneumocystis by X ray, which show early then signs of lung.In clinic it not easy find the diffents from other repiratory virus infection and pneumonia diserse. The used in clinic identited that method is special, sensitive, easy and fast. It can early and fast diagnose MP. It offers a fast serum method for MP clinic diagnose and epidemiology investigation.
1999, 15(10): 887-887.
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Investigations on Rickettsiosis in Shandong Province
Sun Tong
1999, 15(10): 888-889.
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In order to leam the infective and epidemic status of rickensiosis in Shandong province,epidemiological and serological investigations on typhus , Q fever,spotted fever and tsutsugamushi fever were carried out.The results showed that the province was one of the important epidemic typhus district in the country.The cases occurred mainly in the 4th season.The cases aged 15 to 50 accounted for 62.2%.The sex ratio was 1.80∶1(man/female ).Peasant and pupil cases were more common.The infective rates of Q fever were:human 1.18%,goat 13.14% ,cow 3.47% ,dog 32.56% 6,pig 1.75% .The infective rates of spoUed fever were : human 13.07% ,goat 13.58%,cow 43.70% ,donlcey 54.55%.Tsutsuganlushi fever becomes more and more dangerous in the province.The number of epidemic counties increased to about 20 since later 1980.Also 117 tsutsugamushi fever cases occumed in recent 2 years were investigated and analysed.
1999, 15(10): 890-890.
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1999, 15(10): 891-892.
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1999, 15(10): 892-892.
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1999, 15(10): 893-893.
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1999, 15(10): 894-894.
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Preliminary Studies on Cytochrome P450 2E1 and Glutathione S transfarase M1 Polymorphisms and Susceptibility to Gastric Cancer
Cai Lin
1999, 15(10): 895-897.
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The aim of this study was to examine whether cytochrome P450 2E1(CYP2E1)and/or glutathione S-transferase M1(GSTM1)genetic polymorphisms were related to suseptibility to gastric cancer.Genotyping of CYP2E1 and GSTM1 was performed using the polymerase chain reaction on peripheral white blood cell DNA from 91 patients with gastric cancer and 94 controls in a case control study.The results showed that GSTM1-null genotype significantly increased the risk of developing risk of gastric cancer.Persons who carrided the C1/C2 genotpes of CYP2E1 and GSTM1-null had a higher risk of gastric cancer than those with the C1/C1 and GSTM1-nonull genotype,(OR=4 58,85%CI=1 54-14 11).The odds ratio of developing gastric cancer for smoking exposure was strikingly increased in individuals carried the C1/C2 or C2/C2 genotype of CYP2E1 and GSTM1 null(OR=20 00,5%CI=3 69-131 61).These results suggested that CYP2E1 and GSTM1 polymophisms are likely to be associated with gastric cancer susceptibility.
1999, 15(10): 897-897.
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Analysis of the results of hypertension preventiou of Beijing Fangshan Cardiovascular Prevention Program in 1992-1997
Huang Guang-yong
1999, 15(10): 898-899.
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To study the effectiveness of hypertension prevention in rural community, a comprehensive cardiovascular prevention trial through health education and management of hypertension, have been conducted in Fangshan, Beijing suburb since 1992, which include three intervention communities ( IC ) and two control communities (CC).A baseline and two following cross-sectional surveys were carried out in 1991-1992, 1995 and 1997, respectively. Results were showed that: (1) From two following surveys, the proportions of the hypertension patients under management in IC was higher than that in CC, so was the proporttions of taking drugs,especially for female (p0.01 ) ; (2) During 1992-1995, both systolic blood pressure(SBP) and diastolic blood pressure (DBP) of population in IC and DBP of population in CC decreased but the SBP of population in CC increased. During 1995-1997, the blood pressure (BP) of population increased in both IC and CC. During 1992-1997, there was 0.08 and 0.13kPa net decline for SBP and DBP of population in IC, respectively. Results indicated that intervention measures, focused on health education and hypertension control, could increase the proportions of hypertension management and reduce the BP level of population.
1999, 15(10): 900-901.
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Study of Relationship of Diabetes Mellitus with BMI and the Ratio of Waist to Buttook Circle in Shenzhen
Cheng Jinquan
1999, 15(10): 902-903,904.
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The relationship between obesity and the prevalence rates of diabetes mellitus(DM)and impaired glucose tolerance(IGT),A total number of 8200 persons of more than 20 years old having lived in the communities longer than 5 years,was studied in 5 regions of shenzhen in 1997,using stratified cluster sampling method.The study results showed that the prevalence rates of DM and IGT were significantly rose,As BMI and RWBC increased,the prevalence rates of DM and IGT in obesity group(BMI≥25) were 2.6 and 2.3 times in Nonobesity one (BMI25),and that two ratio in more than one group to in less than one were 1∶5 and 1∶2.5.The study result also showed the prevalence rates of DM and IGT increased 0.5% and 1%,As the waist circle increased 1cm.
1999, 15(10): 904-904.
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Follow-up Analysis of The Patients with Impaired Glucose Tolerance
Chen Guanmin
1999, 15(10): 905-905,906.
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One hundred Seventy eight patients with impaired glucose tolerance(IGT)were followed up in the three years.The results showed that the rate of Transformation of IGT to diabetes mellitus(DM)was 35.96%.The higher of 2 hour blood glucose after 75g OGTT,BMI,DBP is the risk factor,The more physical activity is the protective factor for IGT developed into DM.On the other hand,the lower 2 hour blood glucose after 75g OGTT is protective factor for the IGT transformation into normal glucose tolerance(NGT).
1999, 15(10): 906-906.
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1999, 15(10): 907-908,909.
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In order to Study on problems in maternal care of internal immigrants and its solution-finding,an exploratory study has been carried out in five communinities and then a hospigtal based study has been carried out in three hospitals where delivery service is provided.Problems are identified by comparison between women in internal immigrant group and in permanent fesident group and then afctors related to the problems are analyzed.Comparing to permanent resident group,problem of maternal crae in internal immigrant group is obvious:proportions of premature birth and low birth wieight are higher,Apgar Score is lower,proportions of precipitate labor and born before arrival are higher,prenatal death rate is higher,proportion of eclampsism and eclasia is higher and proportion of emergency treatment is higher.By using confounding cntrolled chi-square test,statistical analysis shows that lack of adequate prenatal care is the main cause of the identified problems.Effort should be made to improve maternal care for women in internal immigrants including:strengthening health education,promoting self care and investment in their own health;matching maternakl care services providing to health needs and demands of women in internal immigrants;abandoning illegal delivery and illegal induced abortion services.
1999, 15(10): 909-909.
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1999, 15(10): 910-910.
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1999, 15(10): 911-911,912.
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1999, 15(10): 912-912.
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1999, 15(10): 913-913,914.
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1999, 15(10): 914-914.
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1999, 15(10): 915-915,916.
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1999, 15(10): 916-916.
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1999, 15(10): 917-917,918.
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1999, 15(10): 918-918.
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1999, 15(10): 919-920.
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1999, 15(10): 921-922,923.
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1999, 15(10): 923-923.
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The Study on the Effect of the Balanced Diet in Children's Zinc Bioavailability with the Method of Chemical Metabolic Balance
Zhou hong-bo
1999, 15(10): 924-924,925.
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To observe the function that the balanced diet improved the children's zinc deficiency.Hair zinc weas measured by atomic absorption spectroscopy.According to the value of hair zinc,children were divided into three groups(DB,NL,DL).DB group was given balanced diet.The other group was given low zinc diet.Zinc bioavailability was determined with the method of chemical metabolic balance in the last week of the experiment.At the end of the experiment,hair zinc and zinc apparent absorption amount and bioavailability were higher in DB than in the other groups.The balanced diet improved the children's zinc dificiency.It was an effective method of curing the childern's zinc deficiency.
1999, 15(10): 925-925.
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1999, 15(10): 926-926.
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Study on the Patterns of Potential Yeras of Life Lost(PYLL)in City and Countryside in Zhejiang Province
Zhu Yiming
1999, 15(10): 927-929.
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The death causes were inestigated in three different districts of Zhejiang province.Data were analyzed with the indices,such as PYLL,PYLL% and SPYLL%.The results indicate trauma,Toxicosis,cancer,Cardiovascular and cerebrovascular diseases are main resons that are in charge of the potential years of life lost.In the undeveloped rural areas,infectious diseases are also the very important factors.With the above mentioned analyses,suggestion has been put forward on prevention and control diseases in Zhejiang province.
1999, 15(10): 929-929.
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1999, 15(10): 930-931.
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1999, 15(10): 932-933,934.
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1999, 15(10): 934-934.
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1999, 15(10): 935-935,936.
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1999, 15(10): 936-936.
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1999, 15(10): 937-938.
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1999, 15(10): 938-938.
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1999, 15(10): 939-939.
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1999, 15(10): 940-940.
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1999, 15(10): 941-942.
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1999, 15(10): 943-944.
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1999, 15(10): 944-944.
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1999, 15(10): 945-946.
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Evaluation on Effectiveness of Health Education for Schistosomiasis Control in Highly Endemic Area of Poyang Lake Region
Hu Guanghan
1999, 15(10): 947-948.
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To explore the role of health education in schistosomasis control in highly endemic areas,inhabitants were devided into three groups,the school-children,the adult women and men.After base line survey,aimed health education was carried out in three groups respectively,and the results in experimental groups were compared with those in control groups.After education,the results showed that level of knowledge on anti-schistosomiasis in three groups mentioned above increased significantly,the correct rate of attitude to perform examination and chemotherapy among pupils and adult male men increased remarkably,the qualification rate of value on anti-schistosomiasis increased significantly among adult women,and obedience to examination and chemotherapy for schistosomiasis among adult male men increased significantly,frequency of infested water exposure and rate of infection reduced significantly among school-children and adult women except adult male inhabitants.Health education can efectively control schistosome infection among pupils and adult women,and increase obedience of examination and chemotherapy for schistosomiasis among adult male men.
1999, 15(10): 949-949.
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The Application of DALY in The Evaluation of The Burden of Oceupational Disease in Coal Mine
Yuan Juxiang
1999, 15(10): 950-951.
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Objective To assess the buden of disease for traumatic paraplegia; Methods 26 coal mines were selected to collect data on incidence and prevalence oftraumatic paraplegia. Activities of daily life of the patients were calculated based on a standard questionnaire. DALY was used as an index to measure the burden of disease. Results 325 patients were distributed in the five coal bureaus in 1996.The average burden of disease was 32.55 DALY per 1,000(3915.72/121410). Among the 5 Coal Bureaus, the burden of disease in Tongchuan was the highest (54.47 DALY per l,000 workers), followed by Yangquan (27.85), Fengfeng (26.60), Luan (15.1) and Jincheng(11.71). Conclusion DALY fits to evaluation of the burden of disease in coal mines. The burden of disease for traumatic paraplegia varies grandly among the all coal bureaus searched.
Exploring the approaches of multivariate multilevel model to Meta-analysis
Liu Qiaolan, Li xiaosong, Ni Zongzan
1999, 15(10): 952-953.
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Objective:to explore the applicability of the multivariate multilevel model to Meta Analysis;Methods:focusing on the property of some Meta analysis data with two effect magnitudes,to fit two-level model with two-responses to estimate parameters and to make prediction;Results:with the fitted model,estimates of two mean effect magnitudes with their correlation,and affecting factors were obtained simultaneously;Conclusion:when more than one effect magnitudes exist in data of Meta-analysis,multivariate multilevel model should be employed to estimate the values of all the mean effect magnitudes and their corresponding confidence intervals.Moreover,multivariate multilevel model allows the analysis of correlation among mean effect magnitudes,and the exploration of affecting factors,to be conducted.
1999, 15(10): 953-953.
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1999, 15(10): 954-954,955.
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1999, 15(10): 955-955.
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1999, 15(10): 956-957.
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1999, 15(10): 957-957.
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1999, 15(10): 958-958.
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