Correlation between single nucleotide polymorphism of microRNA target site and gentic susceptibility of gastric cancer

Objective To assess the correlation between single nucleotide polymorphism(SNP)of microRNA(miRNA)target site and the gentic susceptibility of gastric cancer. Methods A 1:1 matched case-control study was adopted in this study.Genotyping was carried out among the subjects.Conditional logistic regression model and multifactor-dimensionality reduction(MDR)method were used to analyze the correlation between SNP of interleukin-1 factor 5(IL-1F5)and genetic susceptibility of gastric cancer.The gene-environment interaction was also analyzed. Results GC genotype in rs2472188 locus(odds ratio OR=1.50,95% confidence interval 95%CI=1.13-1.99)and CT genotype in rs2515401 locus(OR=1.42,95%CI=1.09-1.86)were susceptible genotypes for gastric cancer.Haplotype analysis showed that haplotype 1(CCGCA)(OR=2.08,95%CI=1.27-3.40,haplotype 4(CTATA)(OR=1.98,95%CI=1.48-2.66)and haplotype 5(CTATC)(OR=10.13,95%CI=4.43-23.16)increased the risk of occurrence of gastric cancer,whereas haplotype 2(CTACA)(OR=0.18,95%CI=0.12-0.28),haplotype 3(CTACC)(OR=0.37,95%CI=0.23-0.59)and haplotype 9(GCGTC)(OR=0.39,95%CI=0.27-0.58)decreased the risk. Conclusion Genotypes of GC in rs2472188 locus and CT in rs2515401 locus may be susceptible genotypes for gastric cancer.Combined effects of multigene alleles and multi-locus genotype may have a synergistic effect in the carcinogenesis of gastric cancer.