Protective effect of compound traditional Chinese medicine components on kidney in diabetic rats

Objective To confirm the effect and mechanism of compound traditional Chinese medicine components on prevention and treatment of diabetes and diabetic nephropathy.Methods Intraperitoneal injection of streptozocin(0.055 mg/g)was used to establish diabetes rat model;an experimental model group,high-,medium-,and low-compound traditional Chinese medicine groups,and a positive control group(metformin)were also established.Then a number of related indicators of renal functions were measured.Results The compound traditional Chinese medicine component showed a definite hypoglycemic effects,and reduced levels of blood urine nitrogen(BUN),plasma creatinine(Cr),caspase-3,urine protein(UP)and increased Na⁺,K⁺-ATPase of kidney were observed.Conclusion The compound traditional Chinese medicine components can prevent and treat diabetic nephropathy via inhibiting the apoptosis and improving renal function in diabetic rats.